The bacterial cytoskeleton: more than twisted filaments
- Creators
- Pilhofer, Martin
-
Jensen, Grant J.
Abstract
Far from being simple 'bags' of enzymes, bacteria are richly endowed with ultrastructures that challenge and expand standard definitions of the cytoskeleton. Here we review rods, rings, twisted pairs, tubes, sheets, spirals, moving patches, meshes and composites, and suggest defining the term 'bacterial cytoskeleton' as all cytoplasmic protein filaments and their superstructures that move or scaffold (stabilize/position/recruit) other cellular materials. The evolution of each superstructure has been driven by specific functional requirements. As a result, while homologous proteins with different functions have evolved to form surprisingly divergent superstructures, those of unrelated proteins with similar functions have converged.
Additional Information
© 2012 Elsevier Ltd. Available online 23rd November 2012. Thanks to Matt Swulius, Ariane Briegel, Morgan Beeby and Elitza Tocheva for helpful discussions and comments on the manuscript. Bacterial cytoskeleton research was supported by the Howard Hughes Medical Institute, NIH grant R01 GM094800B, the Center for Environmental Biology Interactions at Caltech and the Bayerische Forschungsstiftung.Attached Files
Accepted Version - nihms-422423.pdf
Supplemental Material - mmc1.mov
Supplemental Material - mmc2.mov
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Additional details
- PMCID
- PMC3597445
- Eprint ID
- 37695
- Resolver ID
- CaltechAUTHORS:20130401-091857529
- Howard Hughes Medical Institute (HHMI)
- R01 GM094800B
- NIH
- Caltech Center for Environmental Biology Interactions
- Bayerische Forschungsstiftung
- Created
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2013-04-01Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field