Origin and Evolution of Dishevelled
Abstract
Dishevelled (Dsh or Dvl) is an important signaling protein, playing a key role in Wnt signaling and relaying cellular information for several developmental pathways. Dsh is highly conserved among metazoans and has expanded into a multigene family in most bilaterian lineages, including vertebrates, planarians, and nematodes. These orthologs, where explored, are known to have considerable overlap in function, but evidence for functional specialization continues to mount. We performed a comparative analysis of Dsh across animals to explore protein architecture and identify conserved and divergent features that could provide insight into functional specialization with an emphasis on invertebrates, especially nematodes. We find evidence of dynamic evolution of Dsh, particularly among nematodes, with taxa varying in ortholog number from one to three. We identify a new domain specific to some nematode lineages and find an unexpected nuclear localization signal conserved in many Dsh orthologs. Our findings raise questions of protein evolution in general and provide clues as to how animals have dealt with the complex intricacies of having a protein, such as Dsh, act as a central messenger hub connected to many different and vitally important pathways. We discuss our findings in the context of functional specialization and bring many testable hypotheses to light.
Additional Information
© 2013 Dillman et al. This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Manuscript received October 23, 2012; accepted for publication December 9, 2012. We thank Byron J. Adams, Geoffrey T. Smith, and Christian A. Grove for their critical reading of the manuscript and Art Vandelay for helpful insights into the details of importing and exporting. This work was supported by a National Institutes of Health (NIH) United States Public Health Service Training Grant (T32GM07616) to A.R.D. and P.J.M., and by the Howard Hughes Medical Institute (with which P.W.S. is an investigator).Attached Files
Published - 251.full.pdf
Supplemental Material - 005314SI.pdf
Supplemental Material - FigureS1.pdf
Supplemental Material - FigureS2.pdf
Supplemental Material - FigureS3.pdf
Supplemental Material - FileS1.pdf
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Additional details
- PMCID
- PMC3564985
- Eprint ID
- 37566
- Resolver ID
- CaltechAUTHORS:20130319-132644894
- NIH Predoctoral Fellowship
- T32GM07616
- Howard Hughes Medical Institute (HHMI)
- Created
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2013-03-20Created from EPrint's datestamp field
- Updated
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2023-10-23Created from EPrint's last_modified field