Published January 2, 2013
| Accepted Version
Journal Article
Open
Pyrrole-Imidazole Polyamides Distinguish Between Double-Helical DNA and RNA
Abstract
Groove specificity: Pyrrole-imidazole polyamides are well-known for their specific interactions with the minor groove of DNA (see scheme). However, polyamides do not show similar binding to duplex RNA, and a structural rationale for the molecular-level discrimination of nucleic acid duplexes by minor-groove-binding ligands is presented.
Additional Information
© 2013 Wiley-VCH Verlag GmbH & Co. Issue published online: 20 Dec 2012. Published online: September 14, 2012. Manuscript Received: 19 July 2012. Support was provided by the NIH GM27681.Attached Files
Accepted Version - nihms414370.pdf
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nihms414370.pdf
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Additional details
- Alternative title
- Py-Im Polyamides Distinguish Double Helical DNA and RNA
- PMCID
- PMC3535541
- Eprint ID
- 36983
- DOI
- 10.1002/anie.201205775
- Resolver ID
- CaltechAUTHORS:20130219-130942144
- GM-27681
- NIH
- Created
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2013-02-19Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field