Published November 10, 2006
| Supplemental Material + Accepted Version
Journal Article
Open
The Genome of the Sea Urchin Strongylocentrotus purpuratus
- Creators
- Sodergren, Erica
- Davidson, Eric H.
-
Cameron, R. Andrew
- Howard-Ashby, Meredith
- Materna, Stefan C.
- Tu, Qiang
- Berney, Kevin
- Su, Yi-Hsien
-
Brown, C. Titus
- Chen, Lili
- Gray, Rachel F.
- Lee, Pei Yun
- Nam, Jongmin
- Oliveri, Paola
- Smith, Joel
- Chow, Elly
- Yuan, Qiu Autumn
- Sea Urchin Genome Sequencing Consortium
Chicago
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Abstract
We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes.
Additional Information
© 2006 American Association for the Advancement of Science. Received for publication 8 August 2006; accepted for publication 17 October 2006. We gratefully acknowledge the following support: BCM-HGSC, National Human Genome Research Institute (NIH) grant 5 U54 HG003273; Naples Workshop, Stazione Zoologica Naples and the Network of Excellence "Marine Genomics Europe" (GOCE-04-505403); M. Elphick, Biotechnology and Biological Sciences Research Council (BBSRC), UK, grant S19916; J. Rast laboratory, Natural Sciences and Engineering Research Council (NSERC) of Canada, Canadian Institutes of Health Research (CIHR), and the Uehara Memorial Foundation; J. A. Coffman, Mount Desert Island Biological Laboratory (MDIBL), NIH grant GM070840; M. C. Thorndyke, K. H. Wilson, F. Hallböök, R. P. Olinski, Swedish Science Research Council, Network of Excellence Marine Genomics Europe (GOCE-04-505403), European Union Research Training Networks FP5 Trophic Neurogenome HPRN-ct-2002-00263, and the Royal Swedish Academy of Sciences, STINT; E. H. Davidson, R. A. Cameron, the Center for Computational Regulatory Genomics (E. H. Davidson, principal investigator) was supported by the NIH grant RR-15044, NSF IOB- 0212869, and the Beckman Institute; also, support for the E. H. Davidson laboratory is from NIH grants HD-37105 and GM61005 and U.S. Department of Energy (DOE) grant DE-FG02-03ER63584; P. Oliveri, Camilla Chandler Frost Fellowship; G. M. Wessel laboratory supported by NSF IOB-0620607 and NIH grant R01 HD028152; B. Brandhorst, K. Bergeron, and N. Chen, NSERC; K. R. Foltz, NSF, IBN-0415581; M. Hahn, NIH grant R01ES006272; D. Burgess, NIH grant GM058231; L. C. Smith, NSF (MCB-0424235); R. O. Hynes, Howard Hughes Medical Institute and National Cancer Institute (NCI) (MIT Cancer Center core grant P30-CA14051); D. McClay, NIH grants GM61464, HD039948, and HD14483; V. D. Vacquier (group leader), G. W. Moy, H. J. Gunaratne, M. Kinukawa, M. Nomura, A. T. Neill, and Y.-H. Su, NIH grant R37-HD12896; R. D. Burke, NSERC and CIHR; L. M. Angerer, National Institute of Dental and Craniofacial Research (NIDCR), R. C. Angerer (NIDCR), Z. Wei (NIDCR), G. Humphrey, National Institute of Child Health and Human Development (NICHD), M. Landrum, National Center for Biotechnology Information (NCBI), O. Ermolaeva (NCBI), P. Kitts (NCBI), K. Pruitt (NCBI), V. Sapojnikov (NCBI), A. Souvorov (NCBI), W. Hiavina (NCBI), S. Fugmann, National Institute on Aging (NIA), M. Dean, National Cancer Institute–Frederick (NCIFCRF) Intramural Research Program of the NIH; P. Cormier, Association pour la Recherche contre la Cancer (ARC), France, grants 4247 and 3507 to P.C., Ligue Nationale contre le Cancer to P.C., Conseil Régional de Bretagne and Conseil Général du Finistère; W. H. Klein, National Eye Institute, NIH grant EY11930, NICHD HD66219, and the Robert A. Welch Foundation (G-0010); N. Adams, NSF grant IBN 0417003 and the Department of the Navy, Office of Naval Research, under Award N00014-05-1-0855; D. Epel, NSF 0417225; A. Hamdoun, F32-HD47136; C. Byrum, American Heart Association grant 0420074Z; K. Walton, U.S. Army Medical Research and Materiel Command grant W81XWH-04-1-0324; J. Stegeman, NIH 2P42 ESO7381; and J. Goldstone, NIH F32 ESO12794Errata
Erratum in Science. 2007 Feb 9;315(5813):766.Attached Files
Accepted Version - nihms-240032.pdf
Supplemental Material - 1133609SeaUrchin-SOM.pdf
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1133609SeaUrchin-SOM.pdf
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Additional details
- PMCID
- PMC3159423
- Eprint ID
- 36689
- DOI
- 10.1126/science.1133609
- Resolver ID
- CaltechAUTHORS:20130130-130039894
- NIH
- 5 U54 HG003273
- Stazione Zoologica Naples and the Network of Excellence
- GOCE-04-505403
- Biotechnology and Biological Sciences Research Council (BBSRC)
- S19916
- Canadian Institutes of Health Research (CIHR)
- Uehara Memorial Foundation
- Mount Desert Island Biological Laboratory (MDIBL)
- NIH
- GM070840
- Swedish Science Research Council
- Network of Excellence Marine Genomics Europe
- GOCE-04-505403
- European Union Research Training Networks FP5 Trophic Neurogenome
- HPRN-ct-2002-00263
- Royal Swedish Academy of Sciences
- NIH
- RR-15044
- NSF
- IOB-0212869
- Caltech Beckman Institute
- NIH
- HD-37105
- NIH
- GM61005
- Department of Energy (DOE)
- DE-FG02-03ER63584
- Camilla Chandler Frost Fellowship
- NSF
- IOB-0620607
- NIH
- R01 HD028152
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- NSF
- IBN-0415581
- NIH
- R01ES006272
- NIH
- GM058231
- NSF
- MCB-0424235
- Howard Hughes Medical Institute (HHMI)
- National Cancer Institute (NCI)
- MIT Cancer Center
- P30-CA14051
- NIH
- GM61464
- NIH
- HD039948
- NIH
- HD14483
- NIH
- R37-HD12896
- National Institute of Dental and Craniofacial Research (NIDCR)
- National Center for Biotechnology Information (NCBI)
- National Institute on Aging (NIA)
- Association pour la Recherche contre la Cancer (ARC)
- 4247
- Association pour la Recherche contre la Cancer (ARC)
- 3507
- Ligue Nationale contre le Cancer
- Conseil Régional de Bretagne and Conseil Général du Finistère
- National Eye Institute
- EY11930
- National Institute of Child Health and Human Development (NICHD)
- HD66219
- Robert A. Welch Foundation
- G-0010
- NSF
- IBN0417003
- Office of Naval Research (ONR)
- N00014-05-1-0855
- NSF
- 0417225
- NIH
- F32-HD47136
- American Heart Association
- 0420074Z
- Army Research Office (ARO)
- W81XWH-04-1-0324
- NIH
- 2P42 ESO7381
- NIH
- F32 ESO12794
- Created
-
2013-01-30Created from EPrint's datestamp field
- Updated
-
2021-11-09Created from EPrint's last_modified field