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Published November 10, 2012 | Supplemental Material + Accepted Version
Journal Article Open

Photoexcitation of tumor-targeted corroles induces singlet oxygen-mediated augmentation of cytotoxicity

Abstract

The tumor-targeted corrole particle, HerGa, displays preferential toxicity to tumors in vivo and can be tracked via fluorescence for simultaneous detection, imaging, and treatment. We have recently uncovered an additional feature of HerGa in that its cytotoxicity is enhanced by light irradiation. In the present study, we have elucidated the cellular mechanisms for HerGa photoexcitation-mediated cell damage using fluorescence optical imaging. In particular, we found that light irradiation of HerGa produces singlet oxygen, causing mitochondrial damage and cytochrome c release, thus promoting apoptotic cell death. An understanding of the mechanisms of cell death induced by HerGa, particularly under conditions of light-mediated excitation, may direct future efforts in further customizing this nanoparticle for additional therapeutic applications and enhanced potency.

Additional Information

© 2012 Elsevier B.V. Received 6 September 2012, Accepted 22 September 2012, Available online 4 October 2012. This work was supported by grants from the NIH (R01 CA140995, and R01 CA129822). Work at Caltech was supported by NIH DK019038 and the Arnold and Mabel Beckman Foundation. Work at the Technion was supported by The Herbert Irving Cancer and Atherosclerosis Research Fund and The United States–Israel Binational Science Foundation.

Attached Files

Accepted Version - nihms-418099.pdf

Supplemental Material - mmc1-5.pdf

Supplemental Material - mmc2.pdf

Supplemental Material - mmc3.pdf

Supplemental Material - mmc4.pdf

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August 19, 2023
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October 20, 2023