Published November 2012
| Supplemental Material + Published
Journal Article
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A copper-catalyzed arylation of tryptamines for the direct synthesis of aryl pyrroloindolines
Abstract
An operationally simple, copper-catalyzed arylation of N-tosyltryptamines provides direct access to C3-aryl pyrroloindolines. A range of electron-donating and electron-withdrawing substituents is tolerated on both the indole backbone and the aryl electrophile. These reactions occur under ambient temperatures and with equimolar quantities of the coupling partners.
Additional Information
© 2012 The Royal Society of Chemistry. Received 9th July 2012, Accepted 9th August 2012. First published on the web 17 Aug 2012. We thank Prof. Brian Stoltz, Dr. Scott Virgil, and the Caltech Center for Catalysis and Chemical Synthesis for access to analytical equipment. We also thank Sigma-Aldrich for a kind donation of chemicals. Fellowship support was provided by the National Science Foundation (Graduate Research Fellowship, M.E.K, Grant no. DGE-1144469). Financial support from the California Institute of Technology and the NIH (NIGMS RGM097582A) is gratefully acknowledged.Attached Files
Published - c2sc20914d.pdf
Supplemental Material - c2sc20914d_supp.pdf
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Additional details
- PMCID
- PMC3480223
- Eprint ID
- 35975
- Resolver ID
- CaltechAUTHORS:20121213-102648677
- DGE-1144469
- NSF Graduate Research Fellowship
- Caltech
- RGM097582A
- NIH
- Created
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2012-12-17Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field