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Published September 2012 | Published
Journal Article Open

The role of FGF signaling in guiding coordinate movement of cell groups: Guidance cue and cell adhesion regulator?

Abstract

Cell migration influences cell-cell interactions to drive cell differentiation and organogenesis. To support proper development, cell migration must be regulated both temporally and spatially. Mesoderm cell migration in the Drosophila embryo serves as an excellent model system to study how cell migration is controlled and influences organogenesis. First, mesoderm spreading transforms the embryo into a multilayered form during gastrulation and, subsequently, cells originating from the caudal visceral mesoderm (CVM) migrate along the entire length of the gut. Here we review our studies, which have focused on the role of fibroblast growth factor (FGF) signaling, and compare and contrast these two different cell migration processes: mesoderm spreading and CVM migration. In both cases, FGF acts as a chemoattractant to guide cells' directional movement but is likely not the only signal that serves this role. Furthermore, FGF likely modulates cell adhesion properties since FGF mutant phenotypes share similarities with those of cell adhesion molecules. Our working hypothesis is that levels of FGF signaling differentially influence cells' response to result in either directional movement or changes in adhesive properties.

Additional Information

© 2012 Landes Bioscience. Submitted: 04-24-12. Revised: 06-07-12. Accepted: 06-12-12. We thank members of the Stathopoulos lab for helpful discussions and, specifically, Amy McMahon for providing some images. This work was supported by postdoctoral fellowships from the American Heart Association to Y.B. and from the Moore Foundation CISR.CACR Bio-Grant to S.K. and by grant 1-FY11-423 from the March of Dimes to A.S.

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August 19, 2023
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