Published October 2012
| Accepted Version
Journal Article
Open
Epithelial to mesenchymal transition: New and old insights from the classical neural crest model
Chicago
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Abstract
The epithelial-to-mesenchymal transition (EMT) is an important event converting compact and ordered epithelial cells into migratory mesenchymal cells. Given the molecular and cellular similarities between pathological and developmental EMTs, studying this event during neural crest development offers and excellent in vivo model for understanding the mechanisms underlying this process. Here, we review new and old insight into neural crest EMT in search of commonalities with cancer progression that might aid in the design of specific therapeutic prevention.
Additional Information
© 2012 Elsevier Ltd. Some of the work reviewed here is based on studies supported by the National Institutes of Health under Award Nos. R03DE022521 to MEB and PS-M, HD037105 and The California Institute of Technology.Attached Files
Accepted Version - nihms374229.pdf
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Additional details
- PMCID
- PMC3435443
- Eprint ID
- 35491
- DOI
- 10.1016/j.semcancer.2012.04.008
- Resolver ID
- CaltechAUTHORS:20121115-133132015
- NIH
- R03DE022521
- NIH
- HD037105
- Caltech
- Created
-
2012-11-16Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field