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Published September 2012 | public
Journal Article

KIR-mediated NK education mediates KIR-associated Crohn's disease susceptibility

Abstract

Purpose/Objective: Natural Killer (NK) cells are innate effector lymphocytes in the host response to infections and tumors through a variety of activating and inhibitory receptors. NK cells require education by self-human leukocyte antigen (HLA) class I molecules through Killer cell Immunoglobulin-like receptors (KIRs) to gain proficient responses. Yet, it remains unknown whether and how KIR-mediated NK education contributes to chronic inflammation in humans.

Additional Information

© 2012 The Author(s). © 2012 Blackwell Publishing Ltd. Article first published online: 12 Sep. 2012.

Additional details

Created:
August 19, 2023
Modified:
October 20, 2023