KIR-mediated NK education mediates KIR-associated Crohn's disease susceptibility

Abstract

Purpose/Objective: Natural Killer (NK) cells are innate effector lymphocytes in the host response to infections and tumors through a variety of activating and inhibitory receptors. NK cells require education by self-human leukocyte antigen (HLA) class I molecules through Killer cell Immunoglobulin-like receptors (KIRs) to gain proficient responses. Yet, it remains unknown whether and how KIR-mediated NK education contributes to chronic inflammation in humans.

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