Novel approach to antitumor antibiotics: Using the power of benzyne in synthesis

Abstract

We have initiated a research program directed toward the tetrahydroisoquinoline (THIQ) antitumor antibiotics, a class of bioactive alkaloids with existing clin. applications. Central to our approach is the development of new aryne annulation methods for the synthesis of isoquinolines. Our initial application of this method in a THIQ synthesis was to a concise asym. total synthesis of (-)-quinocarcin. Our current work in the area will be discussed.

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