Published August 2012
| public
Conference Paper
Signaling through DNA
- Creators
-
Barton, Jacqueline K.
Chicago
Abstract
DNA charge transport chem. offers an opportunity to carry out redox chem. at a distance and thus provides a powerful platform for signaling, whether in the design of new sensors or in activating responses across the genome. Many expts. have now shown that DNA-mediated charge transport can arise over long mol. distances but in a reaction that is exquisitely sensitive to perturbations in the DNA base stack. Studies are described to illustrate this chem., to design new DNA-based sensors, and to characterize how DNA-binding proteins utilize DNA charge transport for long range signaling.
Additional details
- Eprint ID
- 33433
- Resolver ID
- CaltechAUTHORS:20120822-080618079
- Created
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2012-08-27Created from EPrint's datestamp field
- Updated
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2019-10-03Created from EPrint's last_modified field