Occurrence of a Theta-Like Antigen in Rats

Creators: Douglas, Tommy C.

Abstract

The theta antigen, described by Reif and Allen (1), provides a marker for thymus-derived lymphocytes in the mouse. The uses of this antigen system for studies in numerous fields, including immune system development, cellular cooperation, and the distribution of lymphocyte subpopulations, have recently been reviewed (2). Expression of the theta antigen is governed by a single autosomal locus having two alleles, θ^(AKR) and θ^(C3H) (3). After immunization with θ-AKR antigen-bearing cells, spleen cells harvested from mice homozygous for θ^(c3H) have been shown to form plaques against thymus cells from several inbred rat strains as well as against those of mice carrying the θ^(AKR) allele (4). The present study was undertaken in order to clarify the relationship between this rat antigen system and the θ-system of mice.

Additional Information

© 1972 Rockefeller University Press. Beginning six months after publication, RUP grants the public the non-exclusive right to copy, distribute, or display the Work under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons.org/licenses/by-nc-sa/3.0/legalcode. Received for publication 26 May 1972. Supported by Atomic Energy Commission contract AT(04-3)-767 and a National Defense Education Act fellowship. I wish to thank Dr. Ray D. Owen for his counsel and his help in preparation of the manuscript. I also express thanks to Dr. David Dusenbery for his helpful discussions and to Elizabeth Blankenhorn for her technical assistance

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