Published March 1971 | Published
Journal Article Open

Absence of Interference During High-Multiplicity Infection by Clonally Purified Vesicular Stomatitis Virus

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Abstract

Stocks of vesicular stomatitis virus free of defective interfering particles were produced by serial clonal isolation. High-multiplicity infections with these stocks led to no interference or formation of defective interfering particles. Defective interfering particles were generated by three successive passages at high multiplicity.

Additional Information

© 1971 American Society for Microbiology. Received for publication 3 December 1970. This work was supported by an American Cancer Society research grant (E-512). M. S. was supported by a National Science Foundation predoctoral fellowship and D. B. by an American Cancer Society Faculty Research Award.

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