Published March 1977
| public
Journal Article
Low-molecular-weight RNAs of Moloney murine leukemia virus: identification of the primer for RNA-directed DNA synthesis
Abstract
The small RNAs of Moloney murine leukemia virus (M-MuLV) were fractionated into at least 15 species by two-dimensional polyacrylamide gel electrophoresis. The pattern of small RNAs is significantly different from that of Rous sarcoma virus. A subset of the virion small RNAs is associated with the genome RNA in the 70S complex. One of the associated molecules, a cellular tRNA, is tightly bound to the genome RNA and serves as the major primer for M-MuLV RNA-directed DNA synthesis in vitro.
Additional Information
© 1977 American Society for Microbiology. Received for publication 22 October 1976. Supported by Public Health Service grants CA-15166 to J. E. Dahlberg and CA-14051, both from the National Cancer Institute, and a contract from Virus Cancer Program of National Cancer Institute to D. Baltimore. W. A. Haseltine was supported by the Helen Hay Whitney Foundation. D. Baltimore is a Research Professor of American Cancer Society.Additional details
- Eprint ID
- 32838
- Resolver ID
- CaltechAUTHORS:20120801-114336136
- CA-15166
- National Cancer Institute Public Health Service
- CA-14051
- National Cancer Institute Public Health Service
- National Cancer Institute Virus Cancer Program
- Helen Hay Whitney Foundation
- Created
-
2012-08-01Created from EPrint's datestamp field
- Updated
-
2019-10-03Created from EPrint's last_modified field