New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer
- Creators
- Stroncek, David F.
- Berger, Carolina
- Cheever, Martin A.
- Childs, Richard W.
- Dudley, Mark E.
- Flynn, Peter
- Gattinoni, Luca
- Heath, James R.
- Kalos, Michael
- Marincola, Francesco M.
- Miller, Jeffrey S.
- Mostoslavsky, Gustavo
- Powell, Daniel J., Jr.
- Rao, Mahendra
- Restifo, Nicholas P.
- Rosenberg, Steven A.
- O'Shea, John
- Melief, Cornelis J. M.
Abstract
A summit on cellular therapy for cancer discussed and presented advances related to the use of adoptive cellular therapy for melanoma and other cancers. The summit revealed that this field is advancing rapidly. Conventional cellular therapies, such as tumor infiltrating lymphocytes (TIL), are becoming more effective and more available. Gene therapy is becoming an important tool in adoptive cell therapy. Lymphocytes are being engineered to express high affinity T cell receptors (TCRs), chimeric antibody-T cell receptors (CARs) and cytokines. T cell subsets with more naïve and stem cell-like characteristics have been shown in pre-clinical models to be more effective than unselected populations and it is now possible to reprogram T cells and to produce T cells with stem cell characteristics. In the future, combinations of adoptive transfer of T cells and specific vaccination against the cognate antigen can be envisaged to further enhance the effectiveness of these therapies.
Additional Information
© 2012 Stroncek et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Received: 21 February 2012 Accepted: 15 March 2012 Published: 15 March 2012.Attached Files
Published - Stroncek2012p18599J_Transl_Med.pdf
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Additional details
- PMCID
- PMC3362772
- Eprint ID
- 32044
- Resolver ID
- CaltechAUTHORS:20120622-114310759
- Created
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2012-06-22Created from EPrint's datestamp field
- Updated
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2023-03-02Created from EPrint's last_modified field