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Published May 15, 2012 | public
Journal Article

Sibling rivalry in checkpoint control of cell cycle and DNA damage response

Abstract

Maintenance of genomic stability is vital for the survival of all organisms. As a result highly conserved regulatory mechanisms have evolved in eukaryotes that block cell division until the accurate duplication of genomic DNA is completed. These "checkpoint" pathways constitute the key regulatory nodes that ensure genomic stability during normal cell cycle.1,2 Presence of un-replicated and/or damaged DNA results in activation of the DNA damage response (DDR) pathways, which, in turn, negatively regulate the proteins required for cell cycle progression, resulting in checkpoint activation.1 The DDR pathway is thus the predominant regulatory process responsible for the maintenance of genomic stability.

Additional Information

© 2012 Landes Bioscience. Submitted: 04/04/12; Accepted: 04/11/12.

Additional details

Created:
August 19, 2023
Modified:
October 17, 2023