Published May 15, 2012
| public
Journal Article
Sibling rivalry in checkpoint control of cell cycle and DNA damage response
- Creators
- Pabla, Navjotsingh
- Dong, Zheng
Abstract
Maintenance of genomic stability is vital for the survival of all organisms. As a result highly conserved regulatory mechanisms have evolved in eukaryotes that block cell division until the accurate duplication of genomic DNA is completed. These "checkpoint" pathways constitute the key regulatory nodes that ensure genomic stability during normal cell cycle.1,2 Presence of un-replicated and/or damaged DNA results in activation of the DNA damage response (DDR) pathways, which, in turn, negatively regulate the proteins required for cell cycle progression, resulting in checkpoint activation.1 The DDR pathway is thus the predominant regulatory process responsible for the maintenance of genomic stability.
Additional Information
© 2012 Landes Bioscience. Submitted: 04/04/12; Accepted: 04/11/12.Additional details
- Eprint ID
- 31883
- DOI
- 10.4161/cc.20416
- Resolver ID
- CaltechAUTHORS:20120612-133248762
- Created
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2012-06-12Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field