Published January 2012
| Accepted Version
Journal Article
Open
Regulatory gene network circuits underlying T cell development from multipotent progenitors
- Creators
- Kueh, Hao Yuan
- Rothenberg, Ellen V.
Abstract
Regulatory gene circuits enable stem and progenitor cells to detect and process developmental signals and make irreversible fate commitment decisions. To gain insight into the gene circuits underlying T cell fate decision making in progenitor cells, we generated an updated T-lymphocyte developmental gene regulatory network from genes and connections found in the literature. This reconstruction allowed us to identify candidate regulatory gene circuit elements underlying T cell fate decision making. Here, we examine the roles of these circuits in facilitating different aspects of the decision making process, and discuss experiments to further probe their structure and function
Additional Information
© 2011 Wiley Periodicals, Inc. Issue published online: 15 December 2011; Article first published online: 4 October 2011. Based on a presentation to the 8th International Conference on Pathways, Networks and Systems Medicine. www.aegeanconferences.org. We particularly thank Avinash Bhandoola and Brittany Weber (University of Pennsylvania) for sharing of data before publication and valuable criticism of our models. We also thank Rothenberg lab members for useful advice and discussions, as well as Sagar Damle and Bill Longabaugh for advice on Biotapestry. We also thank Mary Yui for a critical reading of this manuscript. This work was supported by a CRI/Irvington Postdoctoral Fellowship to H.Y.K., and NIH grants to E.V.R. (RC2 CA148278, R33 HL089123, and R01 CA90233), the Albert Billings Ruddock Professorship, the Al Sherman Foundation, and the Louis A. Garfinkle Memorial Laboratory Fund.Attached Files
Accepted Version - nihms-320057.pdf
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nihms-320057.pdf
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Additional details
- PMCID
- PMC3242926
- Eprint ID
- 28892
- Resolver ID
- CaltechAUTHORS:20120120-120159296
- CRI/Irvington Postdoctoral Fellowship
- RC2 CA148278
- NIH
- R33 HL089123
- NIH
- R01 CA90233
- NIH
- Albert Billings Ruddock Professorship
- Al Sherman Foundation
- Louis A. Garfinkle Memorial Laboratory Fund
- Created
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2012-01-20Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field