Color Capable Sub-Pixel Resolving Optofluidic Microscope and Its Application to Blood Cell Imaging for Malaria Diagnosis
Abstract
Miniaturization of imaging systems can significantly benefit clinical diagnosis in challenging environments, where access to physicians and good equipment can be limited. Sub-pixel resolving optofluidic microscope (SROFM) offers high-resolution imaging in the form of an on-chip device, with the combination of microfluidics and inexpensive CMOS image sensors. In this work, we report on the implementation of color SROFM prototypes with a demonstrated optical resolution of 0.66 µm at their highest acuity. We applied the prototypes to perform color imaging of red blood cells (RBCs) infected with Plasmodium falciparum, a particularly harmful type of malaria parasites and one of the major causes of death in the developing world.
Additional Information
© 2011 Lee et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Received May 20, 2011; Accepted September 20, 2011; Published October 11, 2011. Editor: Arum Han, Texas A&M University, United States of America. Funding: This work was supported by a grant from the Gates Foundation (OPP1007336 GCE). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We are grateful for the constructive discussions with and generous help from Dr. Benjamin Judkewitz and Mr. Shuo Pang from Caltech. Author Contributions: Conceived and designed the experiments: SAL RL GZ SY AR CY. Performed the experiments: SAL RL. Analyzed the data: GZ SY.Attached Files
Published - Lee2011p16362PLoS_ONE.pdf
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Additional details
- PMCID
- PMC3191177
- Eprint ID
- 28338
- Resolver ID
- CaltechAUTHORS:20111207-094726805
- OPP1007336
- Bill and Melinda Gates Foundation
- Created
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2011-12-20Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field