Published October 21, 2011
| Published + Supplemental Material
Journal Article
Open
Expanding the Repertoire of Natural Product-Inspired Ring Pairs for Molecular Recognition of DNA
Chicago
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Abstract
A furan amino acid, inspired by the recently discovered proximicin natural products, was incorporated into the scaffold of a DNA-binding hairpin polyamide. While unpaired oligomers of 2,4-disubstituted furan amino acids show poor DNA-binding activity, furan (Fn) carboxamides paired with N-methylpyrrole (Py) and N-methylimidazole (Im) rings demonstrate excellent stabilization of duplex DNA as well as discrimination of noncognate sequences, consistent with function as a Py mimic according to the Py/Im polyamide pairing rules.
Additional Information
© 2011 American Chemical Society. ACS AuthorChoice. Received August 30, 2011. Publication Date (Web): September 29, 2011. We are grateful to the National Institutes of Health(GM27681) for research support. J.L.M. (PF-10-015-01-CDD) and D.A.G. (PF-09-262-01-CDD) were supported by postdoctoral fellowships from the American Cancer Society. J.A.R. was supported by an Alexander von Humboldt postdoctoral fellowship.Attached Files
Published - Muzikar2011p16279Org_Lett.pdf
Supplemental Material - ol202285y_si_001.pdf
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ol202285y_si_001.pdf
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Additional details
- PMCID
- PMC3195311
- Eprint ID
- 27899
- Resolver ID
- CaltechAUTHORS:20111122-075248586
- NIH
- GM-27681
- American Cancer Society
- PF-10-015-01-CDD
- American Cancer Society
- PF-09-262-01-CDD
- Alexander von Humboldt Foundation
- Created
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2011-11-22Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field