Electrocardiographic Characterization of Embryonic Zebrafish
Abstract
The zebrafish (Danio rerio) has emerged as one of the primary experimental models of developmental cardiovascular research. Recent progress in flow visualization techniques along with the existing genetic map of the species has made zebrafish amenable to a variety of experiments relating cardiac developmental structure and function. One essential tool in establishing the proper functioning of the heart is the electrocardiogram (ECG). This study presents a methodology whereby the ECGs of embryonic zebrafish could be used in assessing the electrophysiological consequences of genetically-, mechanically-, or pharmacokinetically-induced cardiac perturbations. Five day post-fertilization (dpf) embryos produced repeating bimodal ECGs with clearly distinguished atrial (P) and ventricular (R) depolarization waves. P-R intervals along with P-P intervals are cited.
Additional Information
© 2004 IEEE. Issue Date: 1-5 Sept. 2004. Date of Current Version: 14 March 2005.Additional details
- Eprint ID
- 24989
- Resolver ID
- CaltechAUTHORS:20110823-085037968
- Created
-
2011-08-23Created from EPrint's datestamp field
- Updated
-
2023-03-14Created from EPrint's last_modified field
- Caltech groups
- GALCIT
- Series Name
- Proceedings of Annual International Conference of the IEEE Engineering in Medicine and Biology Society