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Published February 15, 2011 | Supplemental Material + Published
Journal Article Open

Differential electrophysiological response during rest, self-referential, and non-self-referential tasks in human posteromedial cortex

Abstract

The electrophysiological basis for higher brain activity during rest and internally directed cognition within the human default mode network (DMN) remains largely unknown. Here we use intracranial recordings in the human posteromedial cortex (PMC), a core node within the DMN, during conditions of cued rest, autobiographical judgments, and arithmetic processing. We found a heterogeneous profile of PMC responses in functional, spatial, and temporal domains. Although the majority of PMC sites showed increased broad gamma band activity (30-180 Hz) during rest, some PMC sites, proximal to the retrosplenial cortex, responded selectively to autobiographical stimuli. However, no site responded to both conditions, even though they were located within the boundaries of the DMN identified with resting-state functional imaging and similarly deactivated during arithmetic processing. These findings, which provide electrophysiological evidence for heterogeneity within the core of the DMN, will have important implications for neuroimaging studies of the DMN.

Additional Information

© 2011 National Academy of Sciences. Edited by Marcus E. Raichle, Washington University of St. Louis, St. Louis, MO, and approved December 29, 2010 (received for review November 13, 2010). Published online before print January 31, 2011. We thank the patients for participating in this study; Robert Knight and his laboratory members at the University of California, Berkeley, for their assistance with data analysis and useful comments on the manuscript; and Anthony Wagner, Brian Wandell, Bill Newsome, and their laboratory members at Stanford University for their insightful comments throughout the study. This work was supported by a grant from the Milken Family Foundation (to J.P) and by the Stanford University BioX program. Author contributions: J.P. designed research; M.D., B.L.F, S.N., A.M.R., C.C., and J.P. performed research; R.F.D., M.D.G., V.M., D.P.K., and J.P. contributed new reagents/analytic tools; M.D., B.L.F., S.N., A.M.R., J.D.T., and J.P. analyzed data; and M.D., B.L.F., and J.P. wrote the paper.

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Published - Dastjerdi2011p12925P_Natl_Acad_Sci_Usa.pdf

Supplemental Material - pnas.201017098SI.pdf

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