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Published 2010 | public
Book Section - Chapter

Correlated Light and Electron Cryo-Microscopy

Abstract

Light and electron cryo-microscopy have each proven to be powerful tools to study biological structures in a near-native state. Light microscopy provides important localization information, while electron microscopy provides the resolution necessary to resolve fine structural details. Imaging the same sample by both light and electron cryo-microscopy is a powerful new approach that combines the strengths of both techniques to provide novel insights into cellular ultrastructure. In this chapter, the methods and instrumentation currently used to correlate light and electron cryo-microscopy are described in detail.

Additional Information

© 2010 Elsevier Inc. Available online 29 September 2010. We thank Dr. Alasdair McDowall for help with correlated FLM/ECM at Caltech. Work at Caltech was supported by the HHMI, NIH grants R01 AI067548 and P01 GM066521 to GJJ, and gifts from the Gordon and Betty Moore Foundation. Work at Boulder was supported by NIH Research Resource Grant #RR00592 to A. Hoenger. Work at the Max-Planck-Institute of Biochemistry in Martinsried was supported by the European Commission's 7th Framework Programme (grant agreement HEALTH-F4-2008-201648/ PROSPECTS).

Additional details

Created:
August 19, 2023
Modified:
January 13, 2024