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Published December 2010 | Accepted Version
Journal Article Open

Residue-specific incorporation of non-canonical amino acids into proteins: recent developments and applications

Abstract

Residue-specific incorporation of non-canonical amino acids into proteins allows facile alteration and enhancement of protein properties. In this review, we describe recent technical developments and applications of residue-specific incorporation to problems ranging from elucidation of biochemical mechanisms to engineering of protein-based biomaterials. We hope to inform the reader of the ease and broad utility of residue-specific non-canonical amino acid incorporation with the goal of inspiring investigators outside the field to consider applying this tool to their own research.

Additional Information

© 2010 Elsevier Ltd. Available online 9 November 2010. Work at Caltech on non-canonical amino acids is supported by NIH grant GM62523 and by the Institute for Collaborative Biotechnologies under contract W911NF-09-D-0001 with the Army Research Office.

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