Has the Microbiota Played a Critical Role in the Evolution of the Adaptive Immune System?
- Creators
- Lee, Yun Kyung
-
Mazmanian, Sarkis K.
Abstract
Although microbes have been classically viewed as pathogens, it is now well established that the majority of host-bacterial interactions are symbiotic. During development and into adulthood, gut bacteria shape the tissues, cells, and molecular profile of our gastrointestinal immune system. This partnership, forged over many millennia of coevolution, is based on a molecular exchange involving bacterial signals that are recognized by host receptors to mediate beneficial outcomes for both microbes and humans. We explore how specific aspects of the adaptive immune system are influenced by intestinal commensal bacteria. Understanding the molecular mechanisms that mediate symbiosis between commensal bacteria and humans may redefine how we view the evolution of adaptive immunity and consequently how we approach the treatment of numerous immunologic disorders.
Additional Information
© 2011 American Association for the Advancement of Science. We thank members of the Mazmanian laboratory for their critical review of the manuscript. Supported by NIH grants DK078938, DK083633, and AI088626; the Damon Runyon Cancer Research Foundation; and the Crohn's and Colitis Foundation of America (S.K.M.).Attached Files
Accepted Version - nihms314237.pdf
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Additional details
- PMCID
- PMC3159383
- Eprint ID
- 21566
- DOI
- 10.1126/science.1195568
- Resolver ID
- CaltechAUTHORS:20110104-090936027
- NIH
- DK078938
- NIH
- DK083633
- NIH
- AI088626
- Damon Runyon Cancer Research Foundation
- Crohn's and Colitis Foundation of America
- Created
-
2011-01-25Created from EPrint's datestamp field
- Updated
-
2021-11-09Created from EPrint's last_modified field