Chain ordering of hybrid lipids can stabilize domains in saturated/hybrid/cholesterol lipid membranes
- Creators
- Yamamoto, T.
- Brewster, R.
- Safran, S. A.
Abstract
We use a liquid-crystal model to predict that hybrid lipids (lipids that have one saturated and one unsaturated tail) can stabilize line interfaces between domains in mixed membranes of saturated lipids, hybrid lipids, and cholesterol (SHC membranes). The model predicts the phase separation of SHC membranes with both parabolic and loop binodals depending on the cholesterol concentration, modeled via an effective pressure. In some cases, the hybrid lipids can reduce the line tension to zero in SHC membranes at temperatures that approach the critical temperature as the pressure is increased. The differences in the hybrid saturated tail conformational order in bulk and at the interface are responsible for the reduction of the line tension.
Additional Information
© 2010 EPLA. Received 26 May 2010; accepted in final form 8 July 2010; published online 4 August 2010. The authors thank P. Pincus, L. Addadi, D. Andelman, R. Lipowsky, R. Ziblat, and L. Silva for helpful discussions. This research is made possible in part by the historic generosity of the Harold Perlman Family Foundation. This work was supported by the US-Israel Binational Science Foundation and an ISF converging technology grant.Attached Files
Published - Yamamoto2010p11564Epl-Europhys_Lett.pdf
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Additional details
- Eprint ID
- 20540
- Resolver ID
- CaltechAUTHORS:20101026-121025150
- Harold Perlman Family Foundation
- US-Israel Binational Science Foundation
- Israel Science Foundation (ISF)
- Created
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2010-10-27Created from EPrint's datestamp field
- Updated
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2021-11-09Created from EPrint's last_modified field