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Published August 2, 2010 | Supplemental Material + Published
Journal Article Open

Wavefront image sensor chip

Abstract

We report the implementation of an image sensor chip, termed wavefront image sensor chip (WIS), that can measure both intensity/amplitude and phase front variations of a light wave separately and quantitatively. By monitoring the tightly confined transmitted light spots through a circular aperture grid in a high Fresnel number regime, we can measure both intensity and phase front variations with a high sampling density (11 µm) and high sensitivity (the sensitivity of normalized phase gradient measurement is 0.1 mrad under the typical working condition). By using WIS in a standard microscope, we can collect both bright-field (transmitted light intensity) and normalized phase gradient images. Our experiments further demonstrate that the normalized phase gradient images of polystyrene microspheres, unstained and stained starfish embryos, and strongly birefringent potato starch granules are improved versions of their corresponding differential interference contrast (DIC) microscope images in that they are artifact-free and quantitative. Besides phase microscopy, WIS can benefit machine recognition, object ranging, and texture assessment for a variety of applications.

Additional Information

© 2010 Optical Society of America. Received 13 May 2010; revised 9 Jul 2010; accepted 20 Jul 2010; published 23 Jul 2010. We are grateful for the constructive discussions with and the generous help from Professor Paul Sternberg, Professor Scott Fraser, Professor Colin J.R. Sheppard, Shan Shan Kou, Dr. Thomas Vangsness, Dr. Jigang Wu, Emily Mcdowell, Andrea Choe, Sean Pang, Guoan Zheng, Tony Wu, and Anne Sullivan. A portion of this work was done in the UCSB nanofabrication facility, part of the NSF funded NNIN network. The assistance from Caltech Kavli Nanoscience Institute, Watson cleanroom, and Aptina Imaging is much appreciated. This project is funded by the Wallace Coulter Foundation, NSF career award BES-0547657 and NIH R21EB008867.

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Published - Cui2010p11231Opt_Express.pdf

Supplemental Material - 16685.AVI

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