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Published 2009 | public
Book Section - Chapter

A Simple DNA Gate Motif for Synthesizing Large-Scale Circuits

Abstract

The prospects of programming molecular systems to perform complex autonomous tasks has motivated research into the design of synthetic biochemical circuits. Of particular interest to us are cell-free nucleic acid systems that exploit non-covalent hybridization and strand displacement reactions to create cascades that implement digital and analog circuits. To date, circuits involving at most tens of gates have been demonstrated experimentally. Here, we propose a DNA catalytic gate architecture that appears suitable for practical synthesis of large-scale circuits involving possibly thousands of gates.

Additional Information

© 2009 Springer-Verlag Berlin Heidelberg. The authors thank Dave Zhang for discussion of the catalytic mechanism, Marc Riedel for providing example netlists from logic synthesis benchmarks, Virgil Griffith for suggesting useful techniques for DNA sequence design, Ho-Lin Chen and Shuki Bruck for suggesting the connection to relay circuits, David Soloveichik for Mathematica code for simulating chemical reaction networks, and Georg Seeling, Bernard Yurke, and everyone else for discussions and support. This work has been supported by NSF grant no. 0728703 and HFSP award no. RGY0074/2006-C.

Additional details

Created:
August 20, 2023
Modified:
January 12, 2024