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Published March 5, 2010 | public
Journal Article

Angelman Syndrome: Finding the Lost Arc

Abstract

Angelman syndrome is a neurodevelopmental disorder caused by mutations in the maternally inherited UBE3A gene, which encodes a ubiquitin ligase. Greer et al. (2010) now identify a UBE3A substrate called Arc that promotes endocytosis of neuronal AMPA receptors, providing insight into synaptic defects that may underlie the cognitive deficits in Angelman syndrome.

Additional Information

© 2010 Elsevier. Under an Elsevier user license. Available online 4 March 2010.

Additional details

Created:
August 19, 2023
Modified:
October 20, 2023