The Effect of Spatially Inhomogeneous Extracellular Electric Fields on Neurons
Abstract
The cooperative action of neurons and glia generates electrical fields, but their effect on individual neurons via ephaptic interactions is mostly unknown. Here, we analyze the impact of spatially inhomogeneous electric fields on the membrane potential, the induced membrane field, and the induced current source density of one-dimensional cables as well as morphologically realistic neurons and discuss how the features of the extracellular field affect these quantities. We show through simulations that endogenous fields, associated with hippocampal theta and sharp waves, can greatly affect spike timing. These findings imply that local electric fields, generated by the cooperative action of brain cells, can influence the timing of neural activity.
Additional Information
© 2010 the authors. Received July 15, 2009; revised Nov. 10, 2009; accepted Dec. 8, 2009. This work was supported by the Engineering and Physical Sciences Research Council, the Swiss National Foundation, and the National Science Foundation (via a collaborative grant between G.B. and C.K.).Wethank Simal Ozen, Joshua Milstein, and Ueli Rutishauser for ideas and discussions, Ted Carnevale for discussions regarding the numerical implementation and help with NEURON, and Karthik Sarma for numerical procedures and the movies.Attached Files
Published - Anastassiou2010p7115J_Neurosci.pdf
Supplemental Material - 1.pdf
Supplemental Material - Movie_S1.mp4
Supplemental Material - Movie_S2.mp4
Supplemental Material - Movie_S3.mp4
Supplemental Material - Movie_S4.mp4
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Additional details
- PMCID
- PMC6633973
- Eprint ID
- 17587
- Resolver ID
- CaltechAUTHORS:20100225-084528690
- Engineering and Physical Sciences Research Council (EPSRC)
- Swiss National Science Foundation (SNSF)
- NSF
- Created
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2010-03-02Created from EPrint's datestamp field
- Updated
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2021-11-08Created from EPrint's last_modified field
- Caltech groups
- Koch Laboratory (KLAB)