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Published December 2009 | Accepted Version
Journal Article Open

Network design principles from the sea urchin embryo

Abstract

As gene regulatory network models encompass more and more of the specification processes underlying sea urchin embryonic development, topological themes emerge that imply the existence of structural network 'building blocks'. These are subcircuits which perform given logic operations in the spatial control of gene expression. The various parts of the sea urchin gene regulatory networks offer instances of the same subcircuit topologies accomplishing the same developmental logic functions but using different genes. These subcircuits are dedicated to specific developmental functions, unlike simpler 'motifs', and may indicate a repertoire of specific devices of which developmental gene regulatory networks are composed.

Additional Information

© 2009 Elsevier Ltd. Available online 11 November 2009. Research from this laboratory was supported by NIH grants HD37105 and GM61005. I am grateful to Dr. Isabelle Peter, Dr. Joel Smith, and Professor Ellen Rothenberg for extremely valuable comments upon drafts of the manuscript.

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Created:
August 19, 2023
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October 19, 2023