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Published November 23, 2009 | Published
Journal Article Open

Volumetric microvascular imaging of human retina using optical coherence tomography with a novel motion contrast technique

Abstract

Phase variance-based motion contrast imaging is demonstrated using a spectral domain optical coherence tomography system for the in vivo human retina. This contrast technique spatially identifies locations of motion within the retina primarily associated with vasculature. Histogram-based noise analysis of the motion contrast images was used to reduce the motion noise created by transverse eye motion. En face summation images created from the 3D motion contrast data are presented with segmentation of selected retinal layers to provide non-invasive vascular visualization comparable to currently used invasive angiographic imaging. This motion contrast technique has demonstrated the ability to visualize resolution-limited vasculature independent of vessel orientation and flow velocity.

Additional Information

© 2009 Optical Society of America. Received 27 Aug 2009; revised 6 Oct 2009; accepted 6 Nov 2009; published 19 Nov 2009. Help from Susan Garcia and Suman Pilli from UC Davis Eye Center, Sacramento, CA is appreciated. This research was partially supported by NIH grant EY014743.

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