Published July 30, 2007
| Accepted Version
Journal Article
Open
A chronically implantable, hybrid cannula–electrode device for assessing the effects of molecules on electrophysiological signals in freely behaving animals
Abstract
We describe a device for assessing the effects of diffusible molecules on electrophysiological recordings from multiple neurons. This device allows for the infusion of reagents through a cannula located among an array of micro-electrodes. The device can easily be customized to target specific neural structures. It is designed to be chronically implanted so that isolated neural units and local field potentials are recorded over the course of several weeks or months. Multivariate statistical and spectral analysis of electrophysiological signals acquired using this system could quantitatively identify electrical "signatures" of therapeutically useful drugs.
Additional Information
We thank Richard Andersen for his support of this work. This work was funded by a McGrath Foundation grant to Paul H. Patterson, NIH grants R01 EY013337 and R01 EY0155445 to Richard Andersen, and NIH training grant NS007251-18 support for Bradley Greger, and the brain injury fund of Dr. Peter Gruen, which supported Babak Kateb. This work would not have been possible without the precise work of Martin Bak (Micro Probe, Inc.), who implemented the design of the cannula–electrode-pump hybrid system.Errata
Bradley Greger, Babak Kateb, Peter Gruen, Paul H. Patterson, Corrigendum to 'A chronically implantable, hybrid cannula-electrode device for assessing the effects of molecules on electrophysiological signals in freely behaving animals' [J. Neurosci. Methods 163 (2007) 321-325], Journal of Neuroscience Methods, Volume 179, Issue 1, 30 April 2009, Page 157, ISSN 0165-0270, DOI: 10.1016/j.jneumeth.2009.01.014. (http://www.sciencedirect.com/science/article/B6T04-4VJ4B60-1/2/13d3747e34ba0063f1bcb5fef3adfacd)Attached Files
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Additional details
- PMCID
- PMC2683260
- Eprint ID
- 15385
- Resolver ID
- CaltechAUTHORS:20090828-085452917
- R01 EY013337
- NIH
- R01 EY0155445
- NIH
- McGrath Foundation
- NS007251-18
- NIH
- Brain Injury Fund of Dr. Peter Gruen
- Created
-
2009-08-28Created from EPrint's datestamp field
- Updated
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2021-11-08Created from EPrint's last_modified field