Published June 11, 2009
| public
Journal Article
Prion topology and toxicity
- Creators
- Aguzzi, Adriano
- Steele, Andrew D.
Abstract
Inactivation of mahogunin, an E3 ubiquitin ligase, causes a spongiform encephalopathy resembling prion disease. Chakrabarti and Hegde (2009) now report that prion proteins with aberrant topologies inactivate mahogunin, providing a plausible explanation for certain aspects of prion pathology.
Additional Information
©2009 Elsevier Inc. A.A. is supported by the Swiss National Foundation, European Union FP7, and the Stammbach Foundation. A.D.S. is supported by the Broad Fellows in Brain Circuitry program at Caltech.Additional details
- Eprint ID
- 14715
- DOI
- 10.1016/j.cell.2009.05.041
- Resolver ID
- CaltechAUTHORS:20090729-092723886
- Swiss National Foundation
- European Union FP7
- Stammbach Foundation
- Broad Fellows in Brain Circuitry program at Caltech
- Created
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2009-08-07Created from EPrint's datestamp field
- Updated
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2021-11-08Created from EPrint's last_modified field