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Published May 1, 2009 | public
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The deubiquitinase emperor's thumb is a regulator of apoptosis in Drosophila

Ribaya, Jeronimo P.
Ranmuthu, Madhuka
Copeland, Jeff
Boyarskiy, Sergey
Blair, Adrienne P.
Hay, Bruce
Laski, Frank A.
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Abstract

We have characterized the gene emperor's thumb (et) and showed that it is required for the regulation of apoptosis in Drosophila. Loss-of-function mutations in et result in apoptosis associated with a decrease in the concentration of DIAP1. Overexpression of one form of et inhibits apoptosis, consistent with et having an anti-apoptotic function; however, overexpression of a second form of et induces apoptosis, indicating that the two forms of et may have competing functions. et encodes a protein deubiquitinase, suggesting it regulates apoptosis by controlling the stability of apoptotic regulatory proteins.

Additional Information

© 2009 Elsevier. Received 9 May 2008; revised 14 January 2009; accepted 3 February 2009. Available online 13 February 2009. We thank Elisa Park, Mike Montag, Marina Stavchanskiy, and Jessica Wickland for their help and contributions to this work. We also thank Hugo Bellen, the Harvard Exelixis Drosophila stock collection, the Bloomington Drosophila Stock Center, the Szeged Drosophila Stock Centre, and the Drosophila Genetic Resource Center, Kyoto, Japan for providing fly stocks. J.P.R. was supported by the UCLA Genetics Training Grant and a UCLA Dissertation Year Fellowship. This work was funded by grants from the NIH and NSF to F.A.L. and the NIH to B.H.

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