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Published June 15, 2004 | Published
Journal Article Open

Protein-based molecular contrast optical coherence tomography with phytochrome as the contrast agent

Abstract

We report the use of phytochrome A (phyA), a plant protein that can reversibly switch between two states with different absorption maxima (at 660 and 730 nm), as a contrast agent for molecular contrast optical coherence tomography (MCOCT). Our MCOCT scheme builds up a difference image revealing the distribution of phyA within a target sample from pairs of consecutive OCT A-scans acquired at a probe wavelength of 750 nm, both with and without additional illumination of the target sample with 660-nm light. We demonstrate molecular imaging with this new MCOCT modality in a target sample containing a mixture of 0.2% Intralipid and 83 µM of phyA.

Additional Information

© 2004 Optical Society of America. Received January 2, 2004. This research was supported by National Institutes of Health grant EB000243.

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