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Published April 30, 2007 | public
Book Section - Chapter Open

On joint maximum-likelihood estimation of PCR efficiency and initial amount of target

Abstract

We consider the problem of estimating unknown parameters of the real-time polymerase chain reaction (RTPCR) from noisy observations. The joint ML estimator of the RT-PCR efficiency and the initial number of DNA target molecules is derived. The mean-square error performance of the estimator is studied via simulations. The simulation results indicate that the proposed estimator significantly outperforms a competing technique.

Additional Information

© Copyright 2006 IEEE. Reprinted with permission. [Posted online: 2007-04-30]

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