Antisera that Block Cell Division in Developing Eggs of Sea Urchins
- Creators
- Tyler, Albert
- Brookbank, John W.
Abstract
As part of a program of investigation [1, 2, 3] of problems of fertilization and early development, the senior author has prepared antisera against various materials obtained from eggs, sperm, embryos, and adults of several species of sea urchins. In the course of the tests on developing eggs, it was observed that certain of the antisera blocked cleavage very effectively. The various antisera produced against fertilizin were found to be particularly effective cleavage-blocking agents. This seemed of special interest, since fertilizin is known [1-5] to be the sperm-receptor substance that constitutes the surface coat of the egg and is now chemically rather well defined. The cleavage-blocking action was therefore further investigated. In the present paper the results of a survey of the action of various kinds of antisera are presented.
Additional Information
Copyright © 1956 by the National Academy of Sciences Communicated by A. H. Sturtevant, March 9, 1956 This investigation was supported by a research grant (C-2302) from the National Cancer Institute of the National Institutes of Health, Public Health Service. We are indebted to Miss Mary Jones for her excellent assistance in this work. An abstract has been published in Science, 122, 881, 1955.Files
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Additional details
- Eprint ID
- 4849
- Resolver ID
- CaltechAUTHORS:TYLpnas56a
- Created
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2006-09-11Created from EPrint's datestamp field
- Updated
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2019-10-02Created from EPrint's last_modified field