Welcome to the new version of CaltechAUTHORS. Login is currently restricted to library staff. If you notice any issues, please email coda@library.caltech.edu
Published September 2004 | Published
Book Section - Chapter Open

Development of biocompatible parylene neurocages

Abstract

We present a refined method and design for building parylene neurocages for in vitro studies of live neural networks. Parylene neurocages are biocompatible and very robust, making them ideally suited for studying the synaptic connections between individual neurons to gain insight into learning and memory. The neurocage fabrication process is significantly less complex than earlier versions. Previous neurocage designs achieved limited neuronal outgrowth; however, the long-term cell survival rate was <25%. The incorporation of new materials and different anchoring techniques, in addition to some design modifications, as outlined here, have improved the long-term cell survival rate to >50%.

Additional Information

© 2004 IEEE. Reprinted with permission. Publication Date: 1-5 Sept. 2004. This work was funded by the NIH under Award Number R01 NS044134. We would like to thank Mr. Trevor Roper, Mr. Qing He, and Ms. Angelique Johnson for assistance with fabrication and testing.

Attached Files

Published - TOOembc04.pdf

Files

TOOembc04.pdf
Files (2.0 MB)
Name Size Download all
md5:26b7ca0e88f13f0a229454e14bb33f86
2.0 MB Preview Download

Additional details

Created:
August 22, 2023
Modified:
October 17, 2023