Can Specific Mutations Be Induced by Serological Methods?

Creators: Sturtevant, A. H.

Abstract

It has been suggested by Haldane (1935) and by Irwin (1939) that many of the erythrocyte antigens of birds and mammals are rather direct gene products. The reason for this view is that (if we except a portion of the antigens present in species-hybrids of doves) there is a one-to-one correspondence between the presence of specific single genes and specific antigens (see summaries for man by Boyd, 1939, and Wiener, 1935, for rabbits by Castle and Keeler, 1933, for fowls by Todd, 1935, for doves and pigeons by Irwin, 1939). In these cases there is -- with the exception noted -- no evidence for gene interaction, either between allelomorphs or between genes at different loci.

Additional Information

© 1944 by the National Academy of Sciences. Communicated July 5, 1944. This manuscript was written in 1940, and was submitted to Dr. Hyde, whose experiments are referred to as forming much of the basis for the conclusions. Dr. Hyde gave his permission for the reference to his work; but I felt that he would prefer to wait until he could carry out more experiments, and I therefore did not publish. Two factors now influence me to publish the note: Dr. Hyde's death in 1943, without his having published his results; and the results of Dr. Emerson, described in the accompanying paper. The note stands as written in 1940, though a few minor changes might now be desirable. For more recent references, see the paper of Dr. Emerson.

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