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Published January 1, 1973 | Published
Journal Article Open

The nature of the ground states of cobalt(II) and nickel(II) carboxypeptidase A

Abstract

The magnetic susceptibilities of cobalt(II) and nickel(II) derivatives of carboxypeptidase A (CPA) follow the Curie law over a wide temperature range. The observed magnetic moments of Co(II)CPA and Ni(II)CPA are 4.77 ± 0.15 and 2.53 ± 0.10 Bohr Magnetons, respectively. The magnetic and spectral properties of Ni(II)CPA are consistent only with an octahedral ground-state geometry, whereas Co(II)CPA has a probable five-coordinate structure. The results establish ordinary metal-ion ground states for two metallocarboxypeptidase A derivatives which exhibit full peptidase activity.

Additional Information

© 1973 by the National Academy of Sciences. Contributed by Harry B. Gray, November 10, 1972. We thank Barry Dohner for technical assistance. Special thanks are due to Dr. R. J. P. Williams for a stimulating discussion. Our research was supported by the National Science Foundation and Office of Naval Research contract no. N00014-67-A-0094-0013. C.A.R. acknowledges a sabbatical leave from Bucknell University and partial support from a National Science Foundation Science Faculty Fellowship. This is Contribution no. 4588 from the Arthur Amos Noyes Laboratory.

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August 22, 2023
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