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Published 2002 | public
Book Section - Chapter Open

Transcriptional Regulation: a Genomic Overview

Abstract

The availability of the Arabidopsis thaliana genome sequence allows a comprehensive analysis of transcriptional regulation in plants using novel genomic approaches and methodologies. Such a genomic view of transcription first necessitates the compilation of lists of elements. Transcription factors are the most numerous of the different types of proteins involved in transcription in eukaryotes, and the Arabidopsis genome codes for more than 1,500 of them, or approximately 6% of its total number of genes. A genome-wide comparison of transcription factors across the three eukaryotic kingdoms reveals the evolutionary generation of diversity in the components of the regulatory machinery of transcription. However, as illustrated by Arabidopsis, transcription in plants follows similar basic principles and logic to those in animals and fungi. A global view and understanding of transcription at a cellular and organismal level requires the characterization of the Arabidopsis transcriptome and promoterome, as well as of the interactome, the localizome, and the phenome of the proteins involved in transcription.

Additional Information

I wish to acknowledge my colleagues at Mendel Biotechnology for their input and work in our transcription factor genomics research program, as well as for their discussions, insight, and comments. I also wish to acknowledge the work of all those who participated in the Arabidopsis Genome Initiative and sequenced the Arabidopsis genome.

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August 21, 2023
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