Published December 1, 1988
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A long-term in vitro silicon-based microelectrode-neuron connection
Abstract
A novel method for long-term recording and simulation applicable to cultured neurons has been developed. Silicon-based microelectrodes have been fabricated using integrated-circuit technology and micromachining. The chronic connection is made by positioning the tip of the `diving-board electrode' into contact with the top of the cell body. The electrode support structure is then glued to the bottom of the culture dish. Two-way electrical connections to Helisoma B19 neurons have been maintained for up to four days. This capability makes it possible to conduct experiments that are not practical using conventional techniques.
Additional Information
© Copyright 2006 IEEE. Reprinted with permission. Manuscript received February 29, 1988; revised June 22, 1988. This work was supported by NSF Grant BNS8603713. The authors are grateful to Dr. S . B. Kater for supplying Helisoma neurons and for making his laboratory available for experiments, and to Dr. C. Cohan for helping with the Helisoma physiology.Files
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