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Published June 19, 2008 | Published + Supplemental Material
Journal Article Open

The amphioxus genome and the evolution of the chordate karyotype

Abstract

Lancelets ('amphioxus') are the modern survivors of an ancient chordate lineage, with a fossil record dating back to the Cambrian period. Here we describe the structure and gene content of the highly polymorphic approx520-megabase genome of the Florida lancelet Branchiostoma floridae, and analyse it in the context of chordate evolution. Whole-genome comparisons illuminate the murky relationships among the three chordate groups (tunicates, lancelets and vertebrates), and allow not only reconstruction of the gene complement of the last common chordate ancestor but also partial reconstruction of its genomic organization, as well as a description of two genome-wide duplications and subsequent reorganizations in the vertebrate lineage. These genome-scale events shaped the vertebrate genome and provided additional genetic variation for exploitation during vertebrate evolution.

Additional Information

This article is distributed under the terms of the Creative Commons Attribution-Non-Commercial-Share Alike licence (http://creativecommons.org/licenses/by-nc-sa/3.0/), which permits distribution, and reproduction in any medium, provided the original author and source are credited. This licence does not permit commercial exploitation, and derivative works must be licensed under the same or similar licence. Received 8 March 2008; Accepted 4 April 2008. This work was performed under the auspices of the US Department of Energy's Office of Science, Biological and Environmental Research Program, and by the University of California, Lawrence Livermore National Laboratory under contract number W-7405-Eng-48, Lawrence Berkeley National Laboratory under contract number DE-AC02-05CH11231, and Los Alamos National Laboratory under contract number DE-AC02-06NA25396. The Center for Integrative Genomics is supported by a grant from the Gordon and Betty Moore Foundation. D.S.R. acknowledges support from R. A. Melmon. This work was funded by grants from Ministerio de Educacin y Ciencia (J.G.-F.), MEXT, Japan (N.S., A.F., and Y.K.), the 21st Century and Global COEs at Kyoto University (N.S.), grant number P41LM from the National Library of Medicine (J.J. and V.V.K.), BBSRC (T.B. and D.E.K.F.) and the Wellcome Trust (P.W.H.H.).

Attached Files

Published - PUTnat08.pdf

Supplemental Material - PUTnat08sup2.txt

Supplemental Material - PUTnat08sup3.zip

Supplemental Material - PUTnat08sup4.txt

Supplemental Material - PUTnat08sup5.txt

Supplemental Material - PUTnat08sup6.pdf

Supplemental Material - PUTnat08supp1.pdf

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Additional details

Created:
September 14, 2023
Modified:
October 23, 2023