Published February 6, 2009
| Published
Journal Article
Open
Response to comment on "Human-specific gain of function in a developmental enhancer"
Abstract
Duret and Galtier argue that human-specific sequence divergence and gain of function in the HACNS1 enhancer result from deleterious biased gene conversion (BGC) with no contribution from positive selection. We reinforce our previous conclusion by analyzing hypothesized BGC events genomewide and assessing the effect of recombination rates on human-accelerated conserved noncoding sequence ascertainment. We also provide evidence that AT → GC substitution bias can coexist with positive selection.
Additional Information
Copyright 2009 by the American Association for the Advancement of Science. 28 October 2008; accepted 12 January 2009.Attached Files
Published - PRAsci09.pdf
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PRAsci09.pdf
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Additional details
- Eprint ID
- 13778
- Resolver ID
- CaltechAUTHORS:PRAsci09
- Created
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2009-03-23Created from EPrint's datestamp field
- Updated
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2021-11-08Created from EPrint's last_modified field