Published February 1991
| Published
Journal Article
Open
B-cell- and myocyte-specific E2-box-binding factors contain E12/E47-like subunits
Abstract
Recent studies have identified a family of DNA-binding proteins that share a common DNA-binding and dimerization domain with the potential to form a helix-loop-helix (HLH) structure. Various HLH proteins can form heterodimers that bind to a common DNA sequence, termed the E2-box. We demonstrate here that E2-box-binding B-cell- and myocyte-specific nuclear factors contain subunits which are identical or closely related to ubiquitously expressed (E12/E47) HLH proteins. These biochemical function for E12/E47-like molecules in mammalian differentiation, similar to the genetically defined function of daughterless in Drosophila development.
Additional Information
© 1991 by the American Society for Microbiology. Received 6 September 1990/Accepted 21 November 1990. We thank Astar Winoto, Stephen Smale, and Patrick Matthias for generously providing nuclear extracts and Helen Blau for C2C12 cells. C.M. was supported by a fellowship from the Leukemia Society of America. A.V. was supported by a fellowship from the American Cancer Society. This work was supported by Public Health Service grant GM39458.Attached Files
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Additional details
- PMCID
- PMC359799
- Eprint ID
- 11005
- Resolver ID
- CaltechAUTHORS:MURmcb91
- Leukemia Society of America
- American Cancer Society
- GM39458
- NIH
- Created
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2008-06-22Created from EPrint's datestamp field
- Updated
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2021-11-08Created from EPrint's last_modified field