The bivalent side of the nucleus accumbens
Abstract
An increasing body of evidence suggests that the nucleus accumbens (NAcc) is engaged in both incentive reward processes and in adaptive responses to conditioned and unconditioned aversive stimuli. Yet, it has been argued that NAcc activation to aversive stimuli may be a consequence of the rewarding effects of their termination, i.e., relief. To address this question we used fMRI to delineate brain response to the onset and offset of unpleasant and pleasant auditory stimuli in the absence of learning or motor response. Increased NAcc activity was seen for the onset of both pleasant and unpleasant stimuli. Our results support the expanded bivalent view of NAcc function and call for expansion of current models of NAcc function that are solely focused on reward.
Additional Information
Copyright © 2008 Elsevier Inc. Received 6 June 2008; revised 10 September 2008; accepted 21 September 2008. Available online 11 October 2008. We would like to thank Bruce McCandliss and Jason Zevin for their thoughtful discussions about this work. This research was supported in part by the National Institute of Drug Abuse Grant R01 DA018879 (BJC), NIH P50 MH52196 and MH079513, the Mortimer D. Sackler family and Dewitt-Wallace Reader's Digest Foundation. Appendix A. Supplementary data: Supplementary data associated with this article can be found, in the online version, at doi:10.1016/j.neuroimage.2008.09.039.Additional details
- Eprint ID
- 13182
- Resolver ID
- CaltechAUTHORS:LEVni09
- R01 DA018879
- National Institute on Drug Abuse
- P50 MH52196
- National Institutes of Health
- MH079513
- National Institutes of Health
- Mortimer D. Sackler Foundation
- Dewitt-Wallace Reader's Digest Foundation
- Created
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2009-02-02Created from EPrint's datestamp field
- Updated
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2021-11-08Created from EPrint's last_modified field