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Published April 1976 | Published
Journal Article Open

Dimethylsulfoxide-induced differentiation and hemoglobin synthesis in tissue cultures of rat erythroleukemia cells transformed by 7,12-dimethylbenz(a)anthracene

Abstract

Permanent cell lines from transplantable tumors from 7,12-dimethylbenz(a)anthracene-induced erythroleukemia of the rat were established. These cell lines maintain their erythroid nature. Erythroid differentiation can be induced by dimethylsulfoxide. This is shown by decrease in cell size, appearance of red and benzidine positive cells, and induced synthesis of four out of six adult globin chains.

Additional Information

© 1976 National Academy of Sciences. Communicated by Charles Huggins, January 2, 1976. We thank Mrs. A. Rohmann and Mrs. U. Ries for assistance. The work was supported by a research stipend (G.S.) and by a grant (W.O.) from the Deutsche Forschungsgemeinschaft.

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