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Published April 23, 2004 | public
Journal Article

RAGs and Regulation of Autoantibodies

Abstract

Autoreactive antibodies are etiologic agents in a number of autoimmune diseases. Like all other antibodies these antibodies are produced in developing B cells by V(D)J recombination in the bone marrow. Three mechanisms regulate autoreactive B cells: deletion, receptor editing, and anergy. Here we review the prevalence of autoantibodies in the initial antibody repertoire, their regulation by receptor editing, and the role of the recombinase proteins (RAG l and RAG2) in this process.

Additional Information

"Reprinted, with permission, from the Annual Review of Immunology, Volume 22 copyright 2004 by Annual Reviews, www.annualreviews.org" First published online as a Review in Advance on November 10, 2003.

Additional details

Created:
August 22, 2023
Modified:
October 13, 2023