Distribution of enzymes cleaving pyridine nucleotides in animal tissues

Creators: Jacobson, K. Bruce; Kaplan, Nathan O.

Abstract

A number of enzymes capable of splitting the pyridine nucleotides have been found in animal tissues. A portion of the DPNase (1) that hydrolyzes the nicotinamide ribose bond of DPN and TPN was reported in the microsomes of rat liver (1). The DPN pyrophosphorylase, first described by Kornberg (2), has been found by Hogeboom and Schneider to be largely localized in the nucleus (3). In previous investigations (4) an enzyme from pigeon liver which splits DPNH and not DPN at the pyrophosphate linkage was described. The present communication deals with the intracellular distribution of enzymes from various species that attack the pyridine coenzymes at the pyrophosphate linkage. The distribution and properties of DPNases from different species and tissues will also be presented.

Additional Information

© 1957 Rockefeller University Press. This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0. Received for publication, August 17, 1956. Contribution No. 160 of McCollum-Pratt Institute, The Johns Hopkins University, aided by grants from the National Cancer Institute of the National Institutes of Health (Grant No. C-2374 C) and from the American Cancer Society, Inc., as recommended by the Committee on Growth of the National Research Council. [K.B.J. was a] Predoctoral Fellow of the National Cancer Institute of the National Institutes of Health.

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