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Published April 1, 1974 | public
Journal Article Open

Interspersion of repetitive and single-copy sequences in nuclear ribonucleic acid of high molecular weight

Abstract

Nuclear RNA of high molecular weight, approximately 15 to 30 x 10^(3) nucleotides long, isolated from rat ascites cells, has been shown previously to contain both middle repetitive and single-copy sequences. However, it was not known whether these sequences were located on separate molecules or whether they were interspersed within the same molecule. or whether they were interspersed within the same molecule. The present communication distinguishes between these possibilities and shows that a large proportion of nuclear RNA of high molecular weight consists of interspersed middle repetitive and single-copy sequences.

Additional Information

© 1974 by the National Academy of Sciences. Contributed by James Bonner, December 7, 1973. This work was supported by U.S. Public Health Service Grant GM 13762 and the Lucy Mason Clark Fund of the California Institute of Technology.

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August 22, 2023
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